August 7, 2023




U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn:       Jessica Ansart


Re: Yield10 Bioscience, Inc. (the “Company”)
  Registration Statement Filed on Form S-1, as amended (the “Registration Statement”)
  File No. 333-273240


Ladies and Gentlemen:


Pursuant to Rule 461 under the Securities Act of 1933, as amended, the Company hereby respectfully requests that the effective date for the above-referenced Registration Statement be accelerated to 5:00 p.m., Eastern Time, on August 9, 2023, or as soon as practicable thereafter.


Please contact Megan Gates of Covington & Burling LLP at (617) 603-8805 or with any questions you may have regarding this request. In addition, please notify Ms. Gates by telephone when this request for acceleration has been granted.


    Yield10 Bioscience, Inc.
  By: /s/ Oliver P. Peoples
  Name: Oliver P. Peoples
  Title: President & Chief Executive Officer


cc: Megan Gates, Covington & Burling LLP