United States securities and exchange commission logo

                          July 10, 2023

       Dr. Oliver Peoples
       President and Chief Executive Officer
       Yield10 Bioscience, Inc.
       19 Presidential Way
       Woburn, Massachusetts 01801

                                                        Re: Yield10 Bioscience,
Statement on Form S-1
                                                            Filed June 30, 2023
                                                            File No. 333-273070

       Dear Dr. Oliver Peoples:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Nicholas
O'Leary at 202-551-4451 with any questions.


                          Division of Corporation Finance

                          Office of Industrial Applications and

       cc:                                              Joel Papernik, Esq.