United States securities and exchange commission logo July 10, 2023 Dr. Oliver Peoples President and Chief Executive Officer Yield10 Bioscience, Inc. 19 Presidential Way Woburn, Massachusetts 01801 Re: Yield10 Bioscience, Inc. Registration Statement on Form S-1 Filed June 30, 2023 File No. 333-273070 Dear Dr. Oliver Peoples: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Nicholas O'Leary at 202-551-4451 with any questions. Sincerely, Division of Corporation Finance Office of Industrial Applications and Services cc: Joel Papernik, Esq.