Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported) May 11, 2022
(Exact Name of Registrant as Specified in Its Charter)
(State or Other Jurisdiction of Incorporation)
001-33133 04-3158289
(Commission File Number) (IRS Employer Identification No.)
19 Presidential Way, Woburn, Massachusetts
(Address of Principal Executive Offices) (Zip Code)
(617) 583-1700
(Registrant’s Telephone Number, Including Area Code) 
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions ( see General Instruction A.2. below):
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)).
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange on which registered
Common StockYTEN
The Nasdaq Capital Market
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company  
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

Item 2.02 Results of Operations and Financial Condition.
On May 11, 2022, Yield10 Bioscience, Inc. issued a press release announcing the financial results for its fiscal year ended December 31, 2021. A copy of the press release is attached hereto as Exhibit 99.1. This information, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act, or incorporated by reference in any filing under the Securities Act or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
No. Description
Press Release dated May 11, 2022 announcing financial results for the three months ending March 31, 2022
104Cover Page Interactive Data File (embedded within the Inline XBRL document)

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
May 11, 2022By:/s/ Oliver P. Peoples
  Oliver P. Peoples
  President & Chief Executive Officer


Yield10 Bioscience Announces First Quarter 2022 Financial Results
-Management will host a conference call today at 4:30 p.m. (ET) to review
financial results and provide a corporate update
WOBURN, Mass. - May 11, 2022 - Yield10 Bioscience, Inc. (Nasdaq:YTEN) ("Yield10" or the "Company"), an agricultural bioscience company, today reported financial results for the three months ended March 31, 2022.
“The development of Camelina as a commercial oilseed crop addresses three fundamental challenges facing not just our generation but future generations as well: climate change, global food security and plastic waste,” said Oliver Peoples, Ph.D., Chief Executive Officer of Yield10 Bioscience. “We are operationalizing our commercial plan to launch Camelina as a platform crop to supply low-carbon feedstock oil for the biofuel market and to produce omega-3 nutritional oil and PHA bioplastic longer term. In the first quarter, we hired Darren Greenfield to lead seed operations and we recently named Dr. Willie Loh, a former Cargill executive, as a commercial and technical advisor who will provide important insights and guidance as we execute our commercial plans for Camelina oil.

"We are poised to begin engaging growers for seed production under contract in the U.S. and Canada as well as securing supply chain partners for offtake of seed for crushing. This activity has been initiated in 2022 and will continue to ramp up in 2023. In support of this plan, we have identified spring and winter Camelina varieties for initial commercialization in the North American biofuels market.

“Harvest of our 2021/2022 winter field trials is currently underway and will enable us to evaluate the performance of various spring and winter varieties across a range of geographies and provide seed for scale up. Designed to generate proof points on a broad range of Camelina varieties and traits, our 2022 spring field program will be our most extensive to date. Permitting is now complete and planting has begun for this program that is designed to evaluate herbicide tolerance, pest resistance, seed yield, oil content and other key aspects of Camelina performance. In addition, we also expect to

plant PHA Camelina at acre-scale during the second quarter of 2022 and continue to support Rothamsted Research in the development of Camelina omega-3 (DHA+EPA) nutritional oil.

“As 2022 progresses, we expect to continue building our commercial capabilities and to continue protecting our crop discoveries with intellectual property and plant variety registrations in our target markets. As global trends drive interest in Camelina and in new crop yield traits discovered by our team using GRAIN, we remain encouraged by ongoing discussions around collaborative opportunities for Yield10,” said Peoples.

Recent Accomplishments
Establishing commercial capabilities: In the first quarter, Yield10 appointed Darren Greenfield as senior director of seed operations. Mr. Greenfield brings more than 25 years of experience with major agricultural companies managing the development and commercial production of proprietary canola plant varieties. Yield10 recently named Willie Loh, Ph.D. as a special commercial advisor to the Company. Dr. Loh most recently served as Vice President, Market Development, Global Edible Oils division at Cargill and brings more than 25 years of experience in the area of commodity and specialty oils, including omega-3.

2022 seed scale up and field test program underway: Yield10 plans to evaluate candidate Camelina lines for herbicide tolerance to identify lead and back up lines for commercial development and regulatory approval. In addition, a prototype Camelina PHA line will be grown at acre-scale to produce PHA for process development and business development purposes. Further objectives for the field test program include the ongoing evaluation of traits C3007 and C3020 as well as identifying candidate Camelina lines resistant to downy mildew, a fungal pathogen.

2021/2022 winter season field testing and seed scale up on track: Yield10's winter season Camelina program remains on track. The objective of the program is to scale up seed of Camelina line E3902 and two winter Camelina lines, as well as to determine if winter planting in certain U.S. geographies could be viable for spring Camelina lines. The harvest of seed from sites in the U.S. and Canada is ongoing and is expected to be completed by the end of the second quarter of 2022.

New patents granted: A new patent was granted in Australia covering trait C3007 for boosting seed oil content in oilseed crops. Yield10 is the exclusive licensee of this intellectual property from the University of Missouri. A new patent was also granted in Canada covering advanced technology to produce omega-3 oil in Camelina. Yield10 has an exclusive option to secure a commercial license to this technology.

Geopolitical Uncertainty and COVID-19 Impact on Operations

The Company has implemented business continuity plans to address the COVID-19 pandemic and minimize disruptions to ongoing operations. In addition, the conflict in Ukraine has resulted in significant uncertainty in the agriculture and commodities markets, and may have a significant impact on the Company’s business and operations. To date, despite the pandemic, Yield10 has been able to move forward with the operational steps required to execute its 2021-2022 winter field trials and start up its 2022 spring field trials in Canada and the United States. However, it is possible that any potential future closures of research facilities, should they continue for an extended time, or delays in receiving supplies and materials needed to conduct field trials and research, or economic repercussions of the pandemic or other geopolitical uncertainty, such as the ongoing conflict between Ukraine and Russia, could adversely impact the Company's anticipated time frames for evaluating and/or reporting data from our field trials and other work we plan to accomplish during 2022 and beyond.

Cash Position
Yield10 Bioscience is managed with an emphasis on cash flow and deploys its financial resources in a disciplined manner to achieve its key strategic objectives.
Yield10 ended the first quarter of 2022 with $12.7 million in unrestricted cash and investments; a net decrease of $3.3 million from unrestricted cash and investments of $16.0 million reported as of December 31, 2021. The Company used $3.1 million in cash for its operating activities during the three months ended March 31, 2022, in comparison to $2.6 million used for operating activities during the three months ended March 31, 2021. The greater use of cash for operating activities was primarily the result of Yield10's greater net loss of $3.3 million during the first quarter of 2022 in comparison to a net loss of $2.6 million reported for the same quarter of last year. The greater loss is due to the Company's increased operating expenses related to staffing, expanded Camelina spring and winter field trials, increased regulatory-related expenditures as well as due to seed scale up and other early stage seed commercialization activities.
The Company continues to estimate total net cash usage for the full year ended December 31, 2022 in a range of $12.0 to $12.5 million as it continues its controlled growth to develop proprietary Camelina plant varieties and to support the launch of its Camelina products. Yield10's present capital resources are expected to fund its planned operations into the first quarter of 2023. The Company's ability to continue operations after its current cash resources are exhausted is dependent upon its ability to obtain additional financing, including public or private equity financing, secured or

unsecured debt financing, receipt of additional government research grants, as well as licensing or other collaborative arrangements.
Operating Results
Research grant revenue for the three months ended March 31, 2022 was $0.1 million in comparison to grant revenue of $0.2 million recorded during the three months ended March 31, 2021. Research and development expenses were $1.8 million during the first three months of 2022 compared to $1.3 million recorded during the first three months of 2021. General and administrative expenses were $1.7 million and $1.4 million for the three months ended March 31, 2022 and 2021, respectively.
Yield10 reported a net loss of $3.3 million for the quarter ended March 31, 2022, or $0.68 per share, as compared to a net loss of $2.6 million, or $0.60 per share, for the quarter ended March 31, 2021.
Conference Call Information
Yield10 Bioscience management will host a conference call today at 4:30 p.m. (ET) to discuss the first quarter 2022 results. The Company also will provide a corporate update and answer questions from the investor community. A live webcast of the call with slides can be accessed through the Company's website at in the investor relations events section. To participate in the call, dial toll-free 877-709-8150 or 201-689-8354 (international).
To listen to a telephonic replay of the conference call, dial toll-free 877-660-6853 or 201-612-7415 (international) and enter pass code 13728757. The replay will be available until May 25, 2022. In addition, the webcast will be archived on the Company's website in the investor relations events section.
About Yield10 Bioscience
Yield10 Bioscience, Inc. is an agricultural bioscience company that is using its differentiated trait gene discovery platform, the “Trait Factory”, to develop improved Camelina varieties for the production of proprietary seed products, and to discover high value genetic traits for the agriculture and food industries. Our goals are to efficiently establish a high value seed products business based on developing superior varieties of Camelina for the production of feedstock oils for renewable diesel, PHA bioplastics and omega-3 (DHA+EPA) oils, and to license our yield traits to major seed companies for commercialization in major row crops, including corn, soybean and canola. Yield10 is headquartered in Woburn, MA and has an Oilseeds Center of Excellence in Saskatoon, Canada.

For more information about the company, please visit, or follow the Company on Twitter, Facebook and LinkedIn. (YTEN-E)

Safe Harbor for Forward-Looking Statements
This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The forward-looking statements in this release do not constitute guarantees of future performance. Investors are cautioned that statements in this press release which are not strictly historical statements, including, without limitation, expectations regarding Yield10’s cash position, cash forecasts and runway, expectations related to research and development activities, intellectual property, the expected regulatory path for traits, reproducibility of data from field tests, the timing of completion of additional greenhouse and field test studies, the

outcomes of 2021-2022 winter field tests and seed scale-up activities, the signing of research licenses and collaborations, including whether the objectives of those collaborations will be met, whether the Company will be able to generate proof points for traits in development and advance business discussions around its Camelina business plan, the potential impact on operations of the COVID-19 pandemic, the geopolitical uncertainty caused by the conflict between Ukraine and Russia, and value creation as well as the overall progress of Yield10 Bioscience, Inc., constitute forward-looking statements. Such forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated, including the risks and uncertainties detailed in Yield10 Bioscience’s filings with the Securities and Exchange Commission. Yield10 Bioscience assumes no obligation to update any forward-looking information contained in this press release or with respect to the announcements described herein.
Yield10 Bioscience:
Lynne H. Brum, (617) 682-4693,
Investor Relations:
Bret Shapiro, (561) 479-8566,
Managing Director, CORE IR
Media Inquiries:
Eric Fischgrund,
FischTank Marketing and PR


(In thousands, except share and per share amounts)

Three Months Ended
March 31,
Grant revenue$149 $196 
Total revenue149 196 
Research and development1,763 1,316 
General and administrative1,707 1,432 
Total expenses3,470 2,748 
Loss from operations(3,321)(2,552)
Other income (expense):
Other income (expense), net(1)(1)
Total other income (expense)(1)(1)
Loss from operations before income taxes(3,322)(2,553)
Income tax provision(9)(8)
Net loss$(3,331)$(2,561)
Basic and diluted net loss per share$(0.68)$(0.60)
Number of shares used in per share calculations:
Basic and diluted4,888,915 4,296,129 

(In thousands, except share and per share amounts)

March 31,
December 31,
Current Assets:
Cash and cash equivalents$2,128 $5,329 
Short-term investments10,614 10,661 
Accounts receivable124 164 
Unbilled receivables58 34 
Prepaid expenses and other current assets451 436 
Total current assets13,375 16,624 
Restricted cash264 264 
Property and equipment, net945 890 
Right-of-use assets2,259 2,354 
Other assets261 283 
Total assets$17,104 $20,415 
Liabilities and Stockholders’ Equity
Current Liabilities:
Accounts payable$24 $83 
Accrued expenses823 1,136 
Current portion of lease liabilities529 514 
Total current liabilities1,376 1,733 
Lease liabilities, net of current portion2,512 2,649 
Other long-term liabilities
Total liabilities3,893 4,389 
Commitments and contingencies
Stockholders’ Equity:
Preferred stock ($0.01 par value per share); 5,000,000 shares authorized; no shares issued or outstanding
— — 
Common stock ($0.01 par value per share); 60,000,000 shares authorized at March 31, 2022 and December 31, 2021; 4,893,403 and 4,881,851 shares issued and outstanding at March 31, 2022 and December 31, 2021, respectively
49 49 
Additional paid-in capital402,817 402,283 
Accumulated other comprehensive loss(193)(175)
Accumulated deficit(389,462)(386,131)
Total stockholders’ equity13,211 16,026 
Total liabilities and stockholders’ equity$17,104 $20,415 

(In thousands)

Three Months Ended
   March 31,
Cash flows from operating activities  
Net loss$(3,331)$(2,561)
Adjustments to reconcile net loss to cash used in operating activities:  
Depreciation and amortization59 54 
Charge for 401(k) company common stock match45 44 
Stock-based compensation523 324 
Non-cash lease expense95 87 
Deferred income tax provision
Changes in operating assets and liabilities:  
Accounts receivable40 47 
Unbilled receivables(24)(93)
Prepaid expenses and other assets(2)(6)
Accounts payable(59)51 
Accrued expenses(330)(480)
Lease liabilities(122)(109)
Other liabilities(2)(1)
Net cash used in operating activities(3,102)(2,637)
Cash flows from investing activities  
Purchase of property and equipment(114)(101)
Purchase of investments— (869)
Proceeds from the maturity of short-term investments26 3,000 
Net cash (used in) provided by investing activities(88)2,030 
Cash flows from financing activities  
Proceeds from warrants exercised— 3,856 
Proceeds from public offering, net of issuance costs— 11,993 
Taxes paid on employees' behalf related to vesting of stock awards(14)(83)
Net cash (used in) provided by financing activities(14)15,766 
Effect of exchange rate changes on cash, cash equivalents and restricted cash— 
Net (decrease) increase in cash, cash equivalents and restricted cash(3,201)15,159 
Cash, cash equivalents and restricted cash at beginning of period5,593 3,687 
Cash, cash equivalents and restricted cash at end of period$2,392 $18,846