United States securities and exchange commission logo

                            October 13, 2020

       Oliver P. Peoples
       President & Chief Executive Officer
       Yield10 Bioscience, Inc.
       19 Presidential Way
       Woburn, Massachusetts 01801

                                                        Re: Yield10 Bioscience,
Statement on Form S-1
                                                            Filed October 8,
                                                            File No. 333-249388

       Dear Dr. Peoples:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Sergio
Chinos, Staff Attorney, at (202) 551-7844 with any questions.


                            Division of Corporation Finance

                            Office of Manufacturing
       cc:                                              Megan N. Gates