April 8, 2020

Oliver P. Peoples
President & Chief Executive Officer
Yield10 Bioscience, Inc.
19 Presidential Way
Woburn, Massachusetts 01801

       Re: Yield10 Bioscience, Inc.
           Registration Statement on Form S-3
           Filed April 1, 2020
           File No. 333-237539

Dear Dr. Peoples:

       This is to advise you that we have not reviewed and will not review your

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Sergio Chinos, Staff Attorney, at (202) 551-7844 with any


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cc:    Megan N. Gates