OMB APPROVAL

UNITED STATES

OMB Number: 3235-0145

SECURITIES AND EXCHANGE COMMISSION

Expires: February 28, 2009

Washington, D.C. 20549

Estimated average burden hours per response. . 10.4

x

Rule 13d-1(b)

o

Rule 13d-1(c)

o

Rule 13d-1(d)

CUSIP No. 591018809

1.

Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only)
Alger Associates, Inc.                        13-3017981

Fred Alger Management, Inc.            13-2510833

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

x

3.

SEC Use Only

4.

Citizenship or Place of Organization
New York, New York

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
2,976,188

6.

Shared Voting Power
-0-

7.

Sole Dispositive Power
2,976,188

8.

Shared Dispositive Power
-0-

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
2,976,188

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11.

Percent of Class Represented by Amount in Row (9)
12.97%

12.

Type of Reporting Person (See Instructions)
Alger Associates, Inc.                        HC

Fred Alger Management, Inc.            IA

CUSIP No. 591018809

Item 1.

(a)

Name of Issuer
METABOLIX, INC.

(b)

Address of Issuer’s Principal Executive Offices
21 ERIE ST.

CAMBRIDGE, MA 02139

Item 2.

(a)

Name of Person Filing
1.             Alger Associates, Inc.   

2.             Fred Alger Management, Inc.*

(b)

Address of Principal Business Office or, if none, Residence
111 Fifth Avenue, New York, NY 10003

(c)

Citizenship
New York

(d)

Title of Class of Securities
Common Stock

(e)

CUSIP Number
591018809

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

o

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b)

o

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)

o

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d)

o

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).

(e)

x

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f)

o

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g)

o

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h)

o

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

o

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

o

A non-U.S. institution in accordance with § 240.13d–1(b)(1)(ii)(J);

(k)

o

Group, in accordance with § 240.13d–1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with § 240.13d–1(b)(1)(ii)(J), please specify the type of institution:____________________________

CUSIP No. 591018809

Item 4.

Ownership

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a)

Amount beneficially owned:   

2,976,188

(b)

Percent of class:   

12.97%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote   

2,976,188

(ii)

Shared power to vote or to direct the vote    

-0-

(iii)

Sole power to dispose or to direct the disposition of   

2,976,188

(iv)

Shared power to dispose or to direct the disposition of   

-0-

Item 5.

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   o.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person

n/a

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company

n/a

Item 8.

Identification and Classification of Members of the Group

n/a

Item 9.

Notice of Dissolution of Group

n/a

Item 10.

Certification

(a)  The following certification shall be included if the statement is filed pursuant to s240.13d-1(b):

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

FRED ALGER MANAGEMENT, INC.

By: 

/s/ Hal Liebes

Executive Vice President

February 17, 2009

ALGER ASSOCIATES, INC.

By: 

/s/ Hal Liebes

Director

February 17, 2009