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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported) April  27, 2011

METABOLIX, INC.

(Exact Name of Registrant as Specified in Its Charter)

DELAWARE

(State or Other Jurisdiction of Incorporation)

(617) 583-1700

(Registrant’s Telephone Number, Including Area Code)

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

o            Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o            Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o            Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o            Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

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Item 2.02 Results Of Operations and Financial Condition.

On April 27, 2011, Metabolix, Inc. issued a press release announcing the financial results for its quarter ended March 31, 2011. A copy of the press release is attached hereto as Exhibit 99.1. This information, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act, or incorporated by reference in any filing under the Securities Act or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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INDEX TO EXHIBITS

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Exhibit 99.1

Metabolix Reports First Quarter Financial Results and Provides Business Update

CAMBRIDGE, Mass.—(BUSINESS WIRE)— Metabolix, Inc. (NASDAQ: MBLX), a bioscience company focused on bringing environmentally friendly solutions to the plastics, chemicals and energy industries, today reported financial results for the three months ended March 31, 2011.

The Company reported a net loss of $9.6 million or $0.36 per share for the first quarter of 2011 compared to a net loss of $9.8 million or $0.37 per share for the first quarter of 2010.

The Company’s net cash used for operating activities during the first quarter of 2011 was $9.4 million, unchanged from the comparable quarter in 2010. Unrestricted cash and short-term investments at March 31, 2011 totaled $51.9 million. The Company continues to have no debt.

FIRST QUARTER 2011 FINANCIAL OVERVIEW

Metabolix currently manages its finances with an emphasis on cash flow. Metabolix used $9.4 million of cash in operating activities for the first quarter 2011, which is consistent with the comparable quarter in 2010. Net cash used in operating activities reflects the Company’s sales and marketing activities as well as research and product development.

Total revenue in the first quarter of 2011 was $0.3 million, compared to $0.2 million for the respective period in 2010. During the three months ended March 31, 2011 revenue primarily consisted of royalties earned under sublicensing agreements with Tepha, Inc., a related party.

For the three months ended March 31, 2011, total operating expenses were $10.0 million, consistent with the comparable quarter in 2010.

Research and development expenses were $6.2 million for the three months ended March 31, 2011, consistent with the comparable quarter in 2010. Although these expenses were consistent, the Company experienced increases in employee compensation and related benefit expenses and contracted research, which were offset by a decrease in material production costs.

Selling, general and administrative expenses were $3.8 million for the three months ended March 31, 2011 as compared to $3.9 million for the comparable quarter in 2010. The decrease was primarily due to severance costs incurred during the first quarter of 2010.

BUSINESS UPDATE

The Company noted that it has continued to make progress in each of its business and scientific initiatives during the first quarter.

The Company commented that it had continued to develop its portfolio of new customers for Mirel™ bioplastic through the Telles business, including two European producers of compostable bags and a supplier to the marine/aquatic market segment. The Company also disclosed that, due in part to supply constraints for a third party formulation ingredient for certain films, it now expects to reach its Commercial Phase milestone in the second half of fiscal 2011.  The Company believes that this supply issue is short-term in nature and its customer development plans remain otherwise unchanged.

Metabolix also announced that it successfully shipped samples of biobased C4 chemicals to potential customers.  The Company is anticipating customer feedback and will then fine-tune its recovery process, if necessary, to ensure that customer needs are met. The company is using an efficient fermentation and thermal recovery process for its industrial chemicals platform and has demonstrated all steps of its production process for C4 chemicals.  It plans to expand next to C3 chemicals and has established intellectual property for the smaller, but still significant, C5 chemical market. The Company believes that it will be ready to enter the engineering design phase for a commercial facility focused on C4 chemicals by year end, although the timing for commercialization is dependent on

partnership conversations, which are ongoing.

The Company also continued to make progress in its crop science research.  The Company had previously noted that it has completed its first field trial of its oilseeds program with its targeted crop, Camelina.  It has now begun the harvest of its second field trial crop of Camelina in Texas.  The objective of the field trial work is to fine tune the Company’s proprietary gene systems to maximize PHA yields while maintaining healthy, robust plants.  The Company expects further data from the recent trial over the next few months and plans to incorporate those learnings into its scientific and regulatory strategies.  Longer-term, the Company’s crop science initiative is expected to lead to new, more efficient production and recovery processes for a wide range of biobased plastics and chemicals.

Conference Call Information

Richard Eno, the Company’s President and CEO, and Joseph Hill, CFO, will host a conference call on Wednesday, April 27, 2011 at 4:30 p.m. (Eastern) to discuss the results of the first quarter ended March 31, 2011. Management will also provide an update on marketing and customer activity, growth plans for the Telles business, and new technologies. After the presentation management will answer questions from the investor audience. To participate, dial toll-free 1-877-795-3604 or 1-719-325-4752 (international). The pass code is 2769635. The conference call will also be webcast and can be accessed from the Company’s website at www.metabolix.com in the investor relations section.

About Metabolix

Founded in 1992, Metabolix, Inc. is an innovation-driven bioscience company focused on providing sustainable solutions for the world’s needs for plastics, chemicals and energy. The Company is taking a systems approach, from gene to end product, integrating sophisticated biotechnology with advanced industrial practice. Metabolix is now developing and commercializing Mirel(TM), a family of high performance bioplastics which are biobased and biodegradable alternatives to many petroleum-based plastics through Telles, a joint venture between Metabolix and Archer Daniels Midland Company. Metabolix is also developing biosourced industrial chemicals and a proprietary platform technology for co-producing plastics, chemicals and energy, from crops such as oilseeds, switchgrass and sugarcane.

For more information, please visit www.metabolix.com. (MBLX-E)

Safe Harbor for Forward-Looking Statements

This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The forward-looking statements in this release do not constitute guarantees of future performance. Investors are cautioned that statements in this press release which are not strictly historical statements, including, without limitation, statements regarding expected timing of the commercial phase of the ADM collaboration, resolution of raw material supply constraints, and Telles customer sales cycles; expectations for the commercialization of the Company’s industrial chemicals and projected crop science program results; and future research and development, constitute forward-looking statements. Such forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated and are detailed in Metabolix’s filings with the Securities and Exchange Commission, including its 10-K for the year ended December 31, 2010 filed on March 10, 2011. Metabolix assumes no obligation to update any forward-looking information contained in this press release or with respect to the announcements described herein.

METABOLIX, INC.

CONDENSED CONSOLIDATED STATEMENT OF OPERATIONS

UNAUDITED

(in thousands, except share and per share data)

METABOLIX, INC.

CONDENSED CONSOLIDATED BALANCE SHEET

UNAUDITED

(in thousands)

METABOLIX, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

UNAUDITED

(in thousands)